Clinical efficacy of hormone replacement therapy in patients with Menopausal Symptoms
DOI:
https://doi.org/10.63326/z1sn7z68Keywords:
Menopause, Hormone therapy, Efficacy, BiostatisticsAbstract
The objective was to determine the clinical efficacy of hormone replacement therapy (HRT) in patients with climacteric symptoms. A total of 532 patients who attended the urogynecology clinic between April 2023 and November 2025 were included and classified according to diagnosis as premature ovarian insufficiency (n = 72), early menopause (n = 98), and late menopause (n = 362). All participants underwent medical history assessment, physical examination, and laboratory testing in accordance with recommendations established in international guidelines. Prior to treatment initiation, patients received information regarding the benefits and risks associated with HRT. Clinical response was assessed at 2, 6, and 12 months using a 0–10 visual analog scale, where 0 indicated no improvement and 10 indicated complete improvement. Lack of therapeutic response was defined as no reported improvement, including patients who did not initiate or discontinued treatment because of fear of medication use, difficulties accessing the treatment, or insufficient understanding of the information provided. Using a clinical improvement threshold of ≥70%, treatment efficacy was 85.0% (95% CI: 0.82–0.88; p < 0.001), whereas with a threshold of ≥80%, clinical efficacy was 76.9% (95% CI: 0.73–0.80; p < 0.001). No statistically significant differences in efficacy were observed among the treatment groups (p = 0.176). It was concluded that hormone replacement therapy demonstrated high clinical efficacy in patients with climacteric symptoms; however, there is a need to strengthen information regarding its benefits and risks, improve access to diagnostic and therapeutic methods, and ensure multidisciplinary follow-up to promote treatment adherence and optimize clinical outcomes.
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